Ocular Gene Therapy Core

AAV Vectors

The University of Florida Ocular Gene Therapy Core is an adeno-associated virus (AAV) production facility. This core service provides customizable AAV production to match your gene delivery needs.

AAV vectors provide efficient ocular transduction using various combinations of capsids and promoters to drive efficient expression of transgenes. In this image, AAV2 quadruple capsid tyrosine mutant (Y272,444,500,730F) containing the ubiquitous smCBA promoter was used to drive Clarin1-Venus expression in photoreceptors and Müller glia cells (Dinculescu et al. 2016; https://doi.org/10.1371/journal.pone.0148874).

See our Vector Production Options